Juan Cuadrado struck a fine victor for 10-men Juventus in Tuesday's 1-0 Champions League win over Lyon after Gianluigi Buffon had pulled off several stunning saves, including a penalty save.
Full back Rafael, who is also back from injury, will play on the right flank for Lyon, who could be exhausted, having played most of the game at Nice with 10 men. Overall this will be a intriguing fixture.
Lyon have lost 3 of the last 4 matches. Both matches ended in favor of Juventus 0: 1 guest and 2: 1 in his field.
The game had turned from a battle of possession, to a literal battle as Lyon were beginning to grow frustrated with the Old Lady's possession based football. The best thing that could happen for Sevilla fans is is to win by a large margin over Dinamo Zagreb and for Juventus and Lyon to tie.
Fekir should had out Lyon ahead just two minutes after the restart, after a quick Lyon counter-attack saw Lacazette, Fekir and Tolisso all charging down the middle, Fekir spun from his man and took aim, but his strike took a big deflection from Bonucci, and Buffon's incredible improvised save at the last second tipped the ball over the bar.
Juventus were a side capable of challenging for the Champions League every season before the Calciopoli match-fixing scandal of 2006.
Madrid cruises past Legia Warsaw in Champions League
Zinedine Zidane was delighted with the intensity Real Madrid showed in their 6-1 demolition of Real Betis at the weekend. At Lisbon, in another Group F game, Portuguese club Sporting face off against Borussia Dortmund.
With five victories and just a single goal conceded in their last five outings, Juve start as favourites against their inconsistent French opponents, and Buffon believes a win in Lyon will lay down a marker for the 2015 Champions League runners-up.
Lyon and Juventus' only previous meeting was in the quarter finals of the 2013/14 Europa League.
Here's how to watch Lyon vs. Juventus online. Lyon has lost six of its twelve games in all competitions this season but remain in contention for a spot in the Champions League Round of 16.
A safer bet lies with Juventus to win by one goal at 5/2.
Where do you see this game going?
"We're missing some key players but every good team should be able to roll with the punches and adapt", said coach Massimiliano Allegri.