Arsenal will face Bayern Munich, Leicester City will play Sevilla and Manchester City are up against Monaco in the Champions League last 16.
Arsenal lost to the Bundesliga holders in the round of 16 in 2013 and 2014 - Arsene Wenger's side haven't reached the Champions League quarter-finals since 2010.
German worldwide Mesut Ozil seems to be relishing the clash though, in a match that will see him come up against many of his global colleagues.
Leicester, the only debutant in the round of 16, was drawn to play first at Sevilla, the Europa League victor for the past three seasons. "I am responsible for the results so I don't want to escape when I don't meet the expectations of people who love this club", he said.
Extensive research from Europe's leading mathematicians has revealed that the likelihood of Arsenal drawing Bayern Munich was 'at least 100%', suggesting that the way we understand probability is fundamentally flawed.
"Everything is possible, we are the best example of that from last season".
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Instead, they must face Carlo Ancelotti's German champions who finished second in their group, with the first leg in Bavaria.
Despite Bayern's superior head-to-head record against Arsenal in recent seasons, assistant manager Paul Clement said he expected a tougher test but felt the hectic festive schedule will be the undoing of the English Premier League club.
"Many times [in the past] we were in a position where we played at home and we wanted to make the difference and after 10 minutes we conceded a goal and after you think already, "Oh no". "That is what we have to show we have learned".
"This is the Champions League and we've seen in both competitions they are not the superstar team of two years ago, so I genuinely feel Arsenal can come through here". "I think they are playing the best football in France now", he says.
"So I'm convinced that is absolutely right, because I have experience of it". "We are all here to change history".
"Barcelona are a team that our Spanish coach and players know well and we are excited about the prospect of facing them", he added.