That prompted Jose Mourinho to restore the Ivory Coast global to his starting line-up for Wednesday's 2-1 victory over Palace, but he went to ground during the first half in clear discomfort, and a second trip to the turf shortly after the break ended his day as he was replaced in the 52nd minute.
Mourinho must decide whether to recall Eric Bailly, who stepped off the bench at the weekend after recovering from a knee injury, or retain Phil Jones and Marcos Rojo at the heart of the defence.
Mourinho says Rojo is playing phenomenally.
Mkhitaryan was stretchered off in Sunday's home win against Tottenham, but his ankle injury is not as bad as first feared and boss Jose Mourinho hopes to have the Armenian back in contention for the Boxing Day visit of Sunderland.
How Will President-Elect Donald Trump Affect Access To Birth Control?
While the HHS ruling on Planned Parenthood and its affiliates is final, it can be challenged by a Trump administration. Elise Higgins, a lobbyist for Planned Parenthood , says the law has cost the organization about $370,000 annually.
"It's not the same knee, it's the other, the left knee".
"We are doing enough for that [to be in the top six]", said Mourinho after the 2-1 victory at Selhurst Park. "Of course he has a problem with another dimension but he showed wonderful character to try and try, and try until his limit".
Eric Bailly has reassured Manchester United fans that his latest injury is nothing to worry about. I didn't see. The only thing I can say is the referee is good, he's good.
Bailly, 22, made his first Premier League start since damaging knee ligaments against Chelsea on October 23 when he lined up at right-back for Jose Mourinho's team at Selhurst Park. "He is a special guy and his pain level is really high". Now it is the left knee.