Chelsea were bidding to become the only English side ever to win 14 successive top-flight matches in a single season but a pair of Alli headers either side of half-time consigned the Blues to a 2-0 defeat and their first league loss since September 24.
Mauricio Pochettino's side now sit fifth in the table but can leapfrog Arsenal in to the top four and go level on points with Manchester City if they win tonight so it's all to play for in North London.
Spurs were the better side at White Hart Lane and Alli headed in Christian Eriksen's superb cross, to give Mauricio Pochettino's team a first-half lead.
Our club climbed up to third place in the table thanks to Liverpool's 1-0 win over Manchester City this week, but to win this season's Premier League table, it is the leaders Chelsea who must drop points.
There is a long way to go but, on this evidence, last season's title bid was not a one-off.
The build up to the game was massive and both teams lived up to expectation right from the first blast of the whistle. "Tottenham scored in two odd moments at the end of the first half and then after we missed two chances to equalise".
While Chelsea was looking more likely to score on the counterattack in the first half, Tottenham used a break to devastating effect on the stroke of half-time with Alli making the breakthrough.
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The 20-year-old has scored two goals in each of Tottenham's last three matches and seven in his last four.
Chelsea come into this match on a 13-match winning run in the Premier League and if they make it 14 in a row it will be a record for a single top-flight season in England.
Harry Kane believes Tottenham are "bigger, stronger and better" than the team whose title challenge was ended by Chelsea last season. The modern defender needs to be one who can receive the ball under pressure, but the amount of time Luiz spends without accompaniment at the back means he needs an outstanding level of technical excellence and ability to read the game defensively, leaving him as something of a modern Libero.
In the recent match that was played at the Stamford Bridge, Chelsea edged past their arch rivals with a scoreline of 2-1. It is not easy to play against Tottenham.
While Alli's clinical finishing ultimately won the day, Tottenham's victory owed much to their midfield power.
With that run in mind, Spurs will be desperate to end Chelsea's record in front of their supporters tonight.