Tottenham beat Chelsea 2-0 in their most recent Premier League game, before then beating Aston Villa in the FA Cup Third Round by the same scoreline.
Pochettino's side ended Chelsea's run of 13 successive league victories by extending their own winning run to six games and moving up to third place, seven points adrift of the leaders.
Tottenham will be looking to keep the pressure on the top two in the Premier League when they entertain West Bromwich Albion at White Hart Lane on Saturday lunchtime.
Wanyama who left the Saints in June after three seasons at the club has commanded a starting role in the Spurs line up and has recognized Pochettino's hand that helped him settle quickly into the Premier League.
West Brom won their final away match of 2016 - against Southampton - but that was only the Baggies' second win in 10 matches on their travels in all competitions and Tony Pulis's men will have to produce a special performance if they are to shock Spurs; Betway go 8/1 (9.0) that the Baggies pick up maximum points from their trip to north London.
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They have not beaten the Baggies at White Hart Lane in five years and were held to a damaging 1-1 draw towards the end of last season as their title hopes faded.
Spurs only have one player ruled out of the contest, with Erik Lamela still a week away from a return to action after struggling with a hip injury.
West Brom will continue to be without Jonny Evans as he remains out with a calf problem while Saido Berahino will not be involved as he's still not fully fit. However, it's always hard to predict results in the Premier League and that's where Odinbet comes in....
Spurs have not lost at home this season but 31-year-old Scotland global Fletcher is eyeing another positive result that could push West Brom up to seventh.