Handler wouldn't interview the First Lady on "Chelsea" because "she can barely speak English", she told Variety at the Sundance Film Festival.
She also said if President Trump appeared before him right then and there, she'd say, "F**k off".
When asked about whether she would have the First Lady on her show in a video interview with Variety, she said: "Melania? She can barely speak English", Handler said because apparently, it's OK to make fun of the language skills of people from other countries as long as they are on the "other side" of the political aisle.
To judge for yourself, ch-ch-check out the clip (below)!
Now like a lot of America, Handler hasn't shied away from expressing her less than impressed opinions about the Trump family and his run for President.
This is hardly the first time Handler has gone after Melania Trump.
Protesters out ahead of Trump's inauguration
I'm pretty disappointed with Kanye that he says he would have voted for Trump. Numerous artists said they wouldn't take part in Mr Trump's inauguration.
Naturally, the twitterverse had a lot to say about Handler's disrespect, especially considering that Melania Trump actually speaks at least five languages! She publicly supported the democratic candidate, as well as slammed any woman who supported President Trump. For the record, Ms Trump is multilingual and can speak English, Slovenian, French, Italian, and German.
In October, the 46-year-old sent a series of demeaning tweets toward the First Lady.
"Gross. He is the grossest", she said of Mr Trump.
"I bet you that is what he looks like naked, with a little grape between his legs", she said. "I am my own person no man gets to tell me what to do with my body, no-one, not your husband not your politician".
"What do you think about her as the first lady?"
Fox News requested a comment from a representative for Handler, but they did not respond.