Walsh was one of the few women holding a senior role in the Trump White House and was seen as a strong force for organization, though some Trump loyalists viewed her with suspicion because of her roots in the Republican establishment.
A senior administration official told DailyMail.com on Thursday that Walsh had approached senior strategist Steve Bannon about departing the White House to help operate America First, a political nonprofit founded to promote the president's agenda.
White House press secretary Sean Spicer said no more White House staff changes are planned at this time.
It is unclear what the departure means for Preibus, whom some have blamed for Trump's early failures, including the collapse of the GOP health care plan.
Deputy chief of staff Katie Walsh said Thursday she decided to make the move after the Trump-backed health care bill failed last week to amass enough support to clear the House.
White House invites lawmakers to see intelligence material
The House panel's work has been deeply, and perhaps irreparably, undermined by Nunes' apparent coordination with the White House. The NYT has published the names of two White House staffers who assisted House Intel Chair Rep.
Former National Security Adviser Michael Flynn resigned in February after Trump concluded Flynn had given misleading information about contacts with Russian officials. The official said Walsh saw a need to better organize support for the White House's initiatives on the outside. Politico's source for the story was quoted as saying that, "You've got to have somebody from the inside who has the blessing of the man himself" for a move like this.
Making America Great has the financial support of one of Trump's most influential backers, Rebekah Mercer.
Read the latest on Donald Trump's first 100 days in office.
Before serving as chief of staff at the RNC, Walsh worked on a number of political campaigns, including Sen.