Having urged Qatar's neighbours to come up with "reasonable and actionable" demands, the U.S. has sought to distance itself from the crisis.
In Qatar's first response to the demands, government communications director Sheikh Saif bin Ahmed Al Thani said on Saturday that they went far beyond the four governments' stated aim of combating terrorism.
"This list does not satisfy that criteria", he added.
The sanctions have disrupted Qatar's main import routes by land from Saudi Arabia and by sea from big container ships docked in the United Arab Emirates.
The list also demanded that Doha severe all ties with "terrorist organisations", including the Muslim Brotherhood, the Islamic State group, Al Qaeda and Lebanon's Hezbollah.
"The alternative is not escalation, the alternative is parting of ways, because it is very hard for us to maintain a collective grouping", UAE Minister of State for Foreign Affairs Anwar Gargash told reporters. The move by Qatar's neighbours has left it under a de facto blockade.
"The alternative is not escalation", he said.
Faced with a sweeping set of demands, Qatar insisted Friday it can indefinitely survive the economic and diplomatic steps its neighbors have taken to try to pressure it into compliance, even as a top Emirati official warned the tiny country to brace for a long-term economic squeeze.
An unspecified sum in compensation was also requested, and as well as an agreement to shut down Turkey's military presence in Qatar.
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The Doha-based Al Jazeera satellite broadcaster described the demand on its shutting down as a "crime". "We in the network believe that any call for closing down Al-Jazeera is nothing but an attempt to silence the freedom of expression in the region and to suppress people's right to information", the broadcaster said in a statement.
Kuwait is helping mediate the dispute as is the United States, for which it has posed a challenging test since Qatar hosts a base housing the headquarters of US air power in the Middle East as well as 11,000 troops.
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- Stop all contacts with the political opposition in Saudi Arabia, the UAE, Egypt and Bahrain. If this ultimatum is not implemented there will be more than a blockade or breach of diplomatic ties. "The demands are so aggressive that it makes it close to impossible to now see a resolution of that conflict", said Olivier Jakob, a strategist at Switzerland-based oil consultancy Petromatrix.
"I doubt that Qatar will comply with those demands", Truevtsev said.
Saudi Arabia demanded Qatar change its policy, in order to adjust Al Jazeera's broadcasting to the interests of the Gulf States.
Ibrahim Fraihat, associate professor in conflict management and humanitarian action at the Doha Institute, said that Qatar's response is "most likely going to be a very short document".
Abdullah Al-Muhanadi, a retired public sector worker shopping for groceries in Doha on Friday morning, said the boycott must be lifted before negotiations to resolve the dispute could start.
"Because it's no longer about the issue of terrorism or the relationship with Iran - it's about much more than that". "There's a lot on the list that is simply not true or unreasonable, so how can we comply?" he said.