The Russian herself said that she had taken meldonium - which was not banned until the start of a year ago - on medical advice. Eugenie Bouchard called her "a cheater" and added: "I don't think a cheater in any sport should be allowed to play that sport again".
Her all black ensemble is a far cry from the preppy and crisp uniforms usually spotted on centre courts of other grand slams like Wimbledon.
"When the draw came out I knew what a hard matchup this would be, how much excitement was behind this matchup and the hype", she said.
"Early in the third set I hit one serve and I never felt the same after that", Kyrgios said. "It doesn't surprise me", he said after the match.
Williams, the ninth seed, took down Oceane Dodin in straight sets, winning, 7-5, 6-4.
If Maria Sharapova continues to play like she has in her first two matches at the US Open then there are not many players in the field capable of stopping her.
Johnson beats Spieth in playoff at Northern Trust
Victor of this year's Open Championship, Spieth used a hot putter to separate himself from the rest of the field. "He won it. He told his caddie, brother Austin Johnson, that if they got into a playoff, he wouldn't make the same mistake twice.
Svitolina had won the first set of her match against Katerina Siniakova and was leading 2-1 in the second set tiebreak when that match was suspended on Wednesday morning (AEST).
She is branded and nothing Maria Sharapova does on the tennis court for the rest of her career will erase the scarlet letter "M" (for Meldonium, not Maria) that she wears on her custom-designed outfits.
After a disappointing end to the opening set, Sharapova wasted no time in stamping her authority on the second, jumping out to an early 2-0 lead of her own in rather impressive fashion.
Sharapova cut down her miscues to 12 unforced errors in the second set, then just five in the third, and finished with a 39-13 advantage in winners, looking as strong as she did while eliminating No. 2 seed Simona Halep in a three-set thriller at Ashe on Monday.
The 30 year old beat world number two Simona Halep in the opening round of the US Open in NY last night.
"I think with the way that I played Monday night, I don't think there are any more questions", she said when asked whether her spot in the tournament was justified. Babos reacted with a loud yell.
Kenin, 18, reached her dream match by beating another rising Broward County player, 22-year-old Sachia Vickery, 6-3, 4-6, 7-6 (7-0).
The differing reactions in Europe and the United States to her drugs ban were exemplified by the decisions of the French and US Opens when it came to whether to offer wild cards to the 30-year-old Russian, whose ranking was too low to secure an automatic place in the main draw of either event.