It was among thousands of aftershocks recorded in the wake of that earlier quake, which was the most powerful to hit Mexico in 32 years and killed at least 96 people.
A natural disaster with a 6.2 magnitude shook southern Mexico on Saturday and was felt in the capital, where seismic alarms sounded, residents ran into the streets and rescuers briefly stopped combing the rubble left by a bigger tremor earlier this week.
It was not immediately clear if there were any new injuries or damage from the latest quake.
More than 300 people have been reported killed in Tuesday's quake; almost 100 reportedly died in the September 8 temblor.
The upscale Mexico City neighborhood was one of the hardest hit by the quake that killed at least 305 people, with more than a half-dozen collapsed buildings in the immediate vicinity.
Alejandra Castellanos, who was staying in a hotel in the area with her husband, said she was "frightened" when she felt the earth shake for the second time in two weeks.
For Patricia Fernandez Romero, who spent the morning on a yellow folding stool under a handwritten list with the names of the 46 missing, it was remembering how badly her 27-year-old son, Ivan Colin Fernandez, sang and realizing how much she wanted to hear him again.
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Mayor Miguel Angel Mancera said there were no reports of significant new damage in the capital, and rescue efforts related to Tuesday's quake were continuing.
He said that two people had died from heart attacks - local media said the victims were women aged 58 and 83.
US President Donald Trump had offered search-and-rescue assistance to Mexican authorities, saying "God bless the people of Mexico City".
Along a 60-foot stretch of a bike lane in Mexico City's downtown, families huddled under tarps and donated blankets on September 22, awaiting word of loved ones trapped in the four-storey-high pile of rubble behind them.
At the site of an office that collapsed Tuesday, street signs swayed and rescuers briefly evacuated from atop the pile of rubble before returning to work. More than half the known dead 167 perished in the capital.
"They have told us it is well constructed, that it's a bunker", Bueno said of her own home.