At least one other Republican, Senator Rand Paul (KY), has said he would vote against it, and two other Republican Senators, Susan Collins (R-Maine) and Lisa Murkowski (R-Alaska), who voted alongside McCain against the so-called "skinny repeal" (the American Health Care Act of 2017) on July 28 are expected to vote against it.
Trump and Senate Majority Leader Mitch McConnell can afford to lose the support of only two Republicans, assuming all Democrats vote against the measure to repeal and replace the Affordable Care Act better known as Obamacare.
Trump followed up his attacks on McCain Saturday by expressing optimism that Paul and Murkowski could come around to support the bill.
"John McCain shows the same courage in Congress that he showed when he was a naval aviator", said Senate Minority Leader Chuck Schumer, D-N.Y.
The latest bill was introduced by Republican Senators Bill Cassidy and Lindsey Graham, who is a close friend of McCain's.
McCain joined the Kentucky conservative Rand Paul in stating his intention to vote against the bill. That defeat had been seen by many as the end of a seven-year campaign pledge by many Republicans to repeal Obamacare. "Let Arizona down!" Trump wrote about McCain on Twitter early Saturday morning. Trump said. "Alaska had a 200% plus increase in premiums under ObamaCare, worst in the country".
The GOP plan would overhaul Medicaid, end the individual mandate requiring everyone to have health insurance or pay a penalty, and convert the Obamacare individual marketplace into a program by which states would get federal grants to craft their own health care initiatives.
"I can not in good conscience vote for the Graham-Cassidy proposal", McCain said in a statement Friday.
President Donald Trump at the White House in Washington on September 12, 2017. Just because the Graham-Cassidy plan has seemingly fallen short, that doesn't mean Republicans will give up on their plans to change the Obama health law.
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"I think we're going to get the votes", the South Carolina Republican said in an interview that aired Sunday on ABC's "This Week". Ever since the law was signed by President Obama, Republicans had promised to repeal it, and do something different.
In Maine, Collins said there are lots of numbers floating around, and she's awaiting an analysis by the Congressional Budget Office before she makes a final decision.
Surprisingly, Trump appeared to be wooing Paul - the first Republican senator to come out against the bill - to switch: "I know Rand Paul and I think he may find a way to get there for the good of the Party!"
Trump added Friday that he still believes Paul could change his mind.
"Nobody has really offered me that, to say, 'Well, we could spend less, ' " Paul said. He's not a fan of the bill, but reports say he's open to negotiating.
The Senate Finance Committee on Monday will hold a hearing on the Graham-Cassidy bill.
The Senate should heed his advice before acting on a measure opposed by the National Association of Medicaid Directors. Collins and Murkowski were the other two Republicans who opposed McConnell's bill in July.
In a new Washington Post/ABC poll, just 33 percent of voters said they supported the Cassidy-Graham plan, making this last dash at repeal a political burden as well as a whipping test. States that expanded Medicaid under Obamacare would be hardest hit by spending cuts, losing $180 billion from 2020 to 2026, according to the Kaiser Family Foundation. It would also enable states to circumvent ACA requirements for coverage of pre-existing conditions. A public dispute between TV comedian Jimmy Kimmel, whose infant son has a congenital heart defect, and the Senate sponsors took on bitter personal terms this week and demonstrated how little is understood about the legislation.