Mane has been out since September due to a hamstring injury, with Liverpool struggling in the absence of the Senegal worldwide.
Jurgen Klopp has confirmed that Sadio Mane could feature for Liverpool in their Premier League clash with West Ham on Saturday. "He could be ready for 20 or 25 minutes", the German told a press conference yesterday.
Dejan Lovren is also doubtful with a thigh complaint, "I would say it will be really close".
Despite his injury, Mane was included in Senegal manager Aliou Cisse's 25-man squad for their final round of World Cup qualifiers against South Africa on 10 and 14 November.
But he would like Mane to be rested for the second match if Senegal secure their place at Russian Federation 2018 with victory over Bafana Bafana on November 10.
He explained: "We can not ignore the situation of Senegal and say we don't care if they play in the World Cup".
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Adding to his problems, the team's defensive options have been decimated by injuries to Sam Byram, Jose Fonte and James Collins, while right-back Pablo Zabaleta is suspended.
"We are trying to get in contact with Senegal FA". That's the same for Senegal.
"If Senegal get the point they need in first game then ideal situation would be that he doesn't play the second game".
"That would be the ideal situation but we can not decide it".
Speaking at Melwood on Friday afternoon, Klopp discussed the Hammers' disappointing start to the season, insisting "we respect them a lot".
"I think it is quite hard to get a call from the Spanish national team, they have not a lot of weaknesses and not a lot of problems at left-back". That's really important for us. "Training is different and that is where I would love to have more influence in the future".