Researchers around the world, including at the University of Rochester Medical Center (URMC), are pursuing a "universal" flu vaccine, one that would protect against most or all seasonal and pandemic strains of the flu virus. At some point during the development of last year's vaccine, the egg-grown protein acquired a mutation that reduced its effectiveness in warding off the live virus.
"Our data suggest that we should invest in new technologies that allow us to ramp up production of influenza vaccines that are not reliant on eggs", Hensley said. "But in the meantime everyone should get vaccinated each year against flu as even a limited protection against the H3N2 viruses is better than nothing", recommends that the scientific.
"An ideal influenza vaccine would be affordable, provide long-lasting immunity, require few immunizations and would work against all variants of the virus", Weaver said.
The World Health Organization estimates the flu virus results in 1 billion infections, 3 to 5 million cases of severe disease and 300,000 to 500,000 deaths annually.
Following US attack, Trump warns against the return of ISIS
The officials further added that the contents are being investigated and the document supported the belief the act was terrorism. President Donald Trump on Wednesday ordered for robust "extreme vetting" of travellers coming into the United States.
Mice protected by the unconventional vaccine survived exposure to lethal doses of seven of nine widely divergent influenza viruses. "During the 2014-2015 influenza season, clade 3C.2a H3N2 viruses possessing a new predicted glycosylation site in antigenic site B of HA emerged, and these viruses remain prevalent today", wrote the article's authors.
After the experiment, the scientists now are looking forward to conducting more research in order to see whether or not the same vaccine might be applicable to humans too. The shot stimulates immunity against a protein called hemagglutinin, which extends from the surface of the flu virus. The vaccine is made from an inactivated virus that can not transmit infection. It takes two weeks for the flu vaccine to reach maximum protection. "Current H3N2 viruses do not grow well in chicken eggs, and it is impossible to grow these viruses in eggs without adaptive mutations", Hensley said.
"Our experiments suggest that influenza virus antigens grown in systems other than eggs are more likely to elicit protective antibody responses against H3N2 viruses that are now circulating", Hensley said.