Shots were first fired yesterday as between roughly 100 Eritreans and around 30 Afghans queued for free meals at a distribution point near a hospital at around 3.30pm French time.
"Around 150-200 Eritreans migrants armed with sticks were attacking around 20 Afghans", according to reports, with police eventually stepping in to help diffuse the violence and protect the victims.
On Friday, Mr Collomb insisted: "The message I want to get across is that if you want to go to Britain, it's not here you should come".
A sprawling camp known as the "Jungle" was dismantled near Calais in 2016.
Two police officers were injured during the clashes and security reinforcements were deployed.
Clashes between migrants are a frequent occurrence in Calais, where newcomers live scattered in the woods, emerging at night to try waylaying passing trucks.
How did the violence unfold?
Two clashes broke out in the northern port city. Four remain in critical situation.
It is claimed the fighting began after an Afghan fired a gun, resulting in clashes for nearly two hours between around 100 Eritreans and roughly 30 Afghans, who had been waiting for food.
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In total, 22 people were injured, including some with stab wounds, AFP added.
Promising to ease the pressure on Calais, where Britain's southern shores can be seen on a clear day, Collomb said that within two weeks the government would take over control of food distribution from local aid groups and conduct the handouts outside the town.
Why are the migrants there?
A surge in refugee arrivals since Emmanuel Macron urged the United Kingdom to take in more unaccompanied minors last month has seen an already overwrought atmosphere riddled with tensions as displaced people hoped to be granted passage to Britain.
Charities estimate there are around 800 migrants living in Calais but official figures claim there are between 550 and 600.
Collomb appealed to migrants to stay away from Calais, saying the government would not allow them to settle there.
"I have come to reaffirm our unity against the smugglers who feed violence and brawls", Collomb told reporters at the town's police station.
During a visit to Calais last month, French president Emmanuel Macon said Calais would no longer be "a secret gateway to England" for thousands of illegal migrants.
However, humanitarian organizations say Europe's convoluted asylum process makes it almost impossible for people to get the help they need.