With the team expected to have some exhausted legs in the camp following exertions in Thursday's Europa League trip to Russian Federation in eventually beating CSKA Moscow 6-3 on aggregate, Wenger says the physicality and commitment of Welbeck could prove useful.
Spanish midfielder Santi Cazorla remains a long-term absentee with an Achilles injury.
For a promoted team this is quite an achievement with six games of the season still remaining, yet there is little sense that this is an bi-product of Newcastle being a well run club.
Pierre-Emerick Aubameyang is expected to return upfront and could play alongside Welbeck, who has been in electric form of late.
"I will ask the players before the game, if there is any with any doubt about where we are then I will put another player in".
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Ayoze Perez is the club's top scorer with six goals to his name so far this season.
Michael Owen is tipping Newcastle United to end Arsenal's winning run at St James' Park on Sunday.
The only time they have had a longer losing streak against a particular Premier League opponent was from 2009 to 2015, when they suffered 12 consecutive defeats against Manchester City. Wins over Southampton, Huddersfield and Leicester in succession leave the Magpies in 10th place.
"Arsenal had played and won five successive home games prior to their trip to Moscow on Thursday for the second leg of their quarterfinal Europa League tie", Owen told BetVictor.
He said: "In the last games, we have done well even under pressure".
The centre-back has been a mainstay in Newcastle's starting XI under Benitez and his impressive performances have led to British media reports linking him with a £30 million (S$56.1 million) transfer to Premier League rivals Chelsea. His last five games have seen the England global score five goals and he can be backed at [3.3] to find the net. Nine of their 26 wins against the Magpies in the division have been by a single goal, including the last three.