She decided last season to end her racing career and start the next chapter of her life.
It is the first time that the 37-year-old Power, who started in third, has won the race.
She may now turn to her acting and voice-over career, which has seen numerous appearances as herself on talk shows, reality series and hosting gigs.
Patrick's planned 2018 swansong began in the NASCAR Cup series season-opening Daytona 500 with Premium Motorsports where she was collected in a pile-up during the race.
"[ECR] said they looked back at the data and there was a little lift in the middle, a little understeer and back to it and [it] just swung".
"I'm very grateful for everybody and for being able to finish it up like I wanted to", she said.
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"I've had a lot of good fortune here and still had some this month". Dale Earnhardt Jr. took to Twitter after the wreck to thank Patrick for her contributions to the sport. "She's got a great shot because she has a really good vehicle underneath her and a good team".
Barely 10 laps after the Sato/Davison crash, Ed Jones snagged the inside curb at Turn 4 and swung up into the wall; 11 laps after that, the book shut on one of the great pre-race subplots when Danica Patrick lost the rear of her ECR vehicle and ended her career against the Turn 2 barriers. "I don't know if we have a tampering rule in IndyCar, but congrats Will". But she said this week that she didn't have any regrets about her career.
Patrick then spun into the outside wall of Turn 2 on lap 68 of 200, having dropped her left-front tyre over the white line, but was at a loss to explain the crash. "I can't describe it".
Patrick, who shot to prominence by finishing fourth as a rookie in 2005, announced earlier this year that she would step away from racing after Sunday's race. "I've had so many wins, so many poles". I never thought I'd win in front of so many people. He's one of the most decorated drivers of his generation. "I'm not going to miss the nervous feeling one bit".
Among other drivers who exited due to mishaps were three-time victor Helio Castroneves (lap 147) and 2013 victor Tony Kanaan (188). He posted throughout the day about the race, and he even streamed the whole event from inside his vehicle.