Low included Sane in his original 27-man squad and it seemed a formality he would make the final 23.
Alongside Sane, Bayer Leverkusen duo Bernd Leno and Jonathan also miss out, as does Freiburg striker Nils Petersen.
The defending champions and perennial dark horses had both named provisional squads in recent weeks, but made the card calls and announced their final panels ahead of Tuesday's Federation Internationale de Football Association deadline. Should they be victorious, Joachim Low's team would become the first since Brazil in 1962 to successfully retain the World Cup, and only the third in history after Italy also managed it in 1938.
He only has 12 caps to his name, just six of those have been starts, and he is yet to score for his country but you can not say that he has not been given a fair chance to prove himself; four of his six starts have come in his last six outings.
Explaining his decision to reporters (via the Mirror), Low revealed that he doesn't think Sane is ready for the worldwide stage, stating that he is "yet to arrive".
New US tariffs would make trade deals void, China says
Ross's Commerce Department, and they have suggested that it is merely a bargaining ploy as part of trade negotiations. The two sides began a new round of talks in Beijing this weekend aimed at settling a simmering trade dispute.
"In the end it was tight, both (Sane and Brandt) have great qualities, are fast and dribble", he said at a press conference, quoted by sport.de.
Germany must be the envy of most other national teams.
But he is a far better and more mature player and has come on in leaps and bounds after two years in England under the tutelage of Pep Guardiola.
Speaking on Monday, Low underlined the importance of multi-functional players in a squad for a major tournament.