KSHB-TV reports the two deputies were transporting prisoners around 11:30 a.m. when they were "overcome" and were shot.
In two separate incidents, three people were shot and killed by police in Kansas City, Missouri, on Thursday.
'Our hearts break for our brothers and sisters at Wyandotte County Sheriff's Office as well as for the loved ones of the deputies shot today, one of whom has died. The suspect was also shot during the incident and taken to a local hospital.
The suspect is undergoing surgery, but his condition was not released.
Officials said the critically injured deputy is a woman but did not release her name.
Zach Blair, with the Kansas City, Kansas, Police Department says they are not looking for any other suspects.
They may have been overcome with their own weapons, according to Wyandotte County sheriff's spokeswoman Maj. A male deputy died from his injuries. Rohrer had been on the force for seven years, the Wyandotte County Sheriff's office said. The surviving deputy is female.
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Colón says he's "very confident it was a last-resort situation to ensure the safety of the public".
Kansas City, Kansas, Mayor Dave Alvey spoke Saturday morning, thanking a laundry list of law enforcement entities for their help in responding to the shooting, calling it "a heroic act", as well as the staff of the University of Kansas Hospital.
The shooting is believed to have happened in the gated parking lot behind the court services building.
Terry Zeigler, chief of the KCKPD, told the paper the deputies were transporting the inmate from the jail, which is across the street.
"Today's bad events in Kansas City bitterly remind us once again of the dangers and sacrifices faced every day by law enforcement officers throughout our state and nation", Kansas Attorney General Derek Schmidt said. Their conditions are unknown.
Authorities said it was too early in the investigation to publicly detail how the shootings could have happened.