Two teams are going to try and win - each team using their weapons.
Portugal's Ronaldo has scored 85 goals in 153 appearances and looks in inspiring form, the last group game where he missed a penalty and was involved in a VAR-influenced decision getting away with a yellow card after pulling down an Iran defender.
At the other end is Suarez with 53 goals from 101 games but numerous controversies behind him including a nine-game worldwide ban for biting Italy's Giorgio Chiellini four years ago.
Despite the high-stakes nature of the fixture, Tabaraz has reported his camp is a relaxed one having been impressed by what he has seen in Uruguay's victories over Egypt, Saudi Arabia and Russian Federation.
Uruguay defender Jose Gimenez, who scored their first goal of the tournament, should also be ready to return after sitting out their final group game with Russian Federation.
"They are a typical South American side", said Portugal coach Fernando Santos.
Since 1966, only Grzegorz Lato & Andrzej Szarmach (five for Poland) and Michael Ballack and Miroslav Klose (five for Germany) have combined for more World Cup goals than Uruguay's Edinson Cavani and Luis Suarez (4).
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Portugal: Rui Patricio, Pepe, Raphael Guerreiro, Jose Fonte, Cristiano Ronaldo, Joao Mario, Bernardo Silva, William Carvalho, Ricardo Pereira, Goncalo Guedes, Adrien Silva.
Oscar Tabarez's side were one of just three sides to emerge from the group stages with a 100% record and were quickly into their stride against the European champions.
With Suarez, the clashes have been more common.
The first FIFA World Cup meeting between Uruguay and Portugal is bound to be a doozy.
Tabarez, who has coached Uruguay since 2006, has never hidden his admiration for his captain. Uruguay beat Russian Federation 3-0 while Portugal were held 1-1 by Iran, with a last-minute penalty.
On the same day Lionel Messi was sent home in Argentina's loss, the other "GOAT" at this tournament was also eliminated.