Speaking from his home in the capital, Harare, on Sunday, the former president again said he had been "sacked" as part of a military coup and that he left office in order to "avoid conflict".
The former first lady's political ambitions were beleived by many to be the catalyst for the army's decision to intervene in November.
"I can not vote for those who tormented me", he said.
Media were allowed through the gates of the luxury sprawling mansion where chairs were set up on a formal lawn in front of a blue-tiled pagoda to listen.
Mugabe denied meeting MDC Alliance leader Nelson Chamisa after his ouster, let alone funding his campaigns as was widely believed but said he will vote for him anyway, confirming what the young presidential hopeful has been bragging about that he has Mugabe's vote guaranteed.
During the address, he also addresses rumors that he planned to have his wife, Grace Mugabe take over, calling them "utter nonsense".
Priyanka Chopra, Nick Jonas engaged, reports United States media
But Priyanka's exit isn't the only thing that is holding the film - which is being shot in part in the United Kingdom - back. Last month, the couple spent time in India and Chopra acted as Jonas' plus-one at a family member's wedding.
"I never thought (Mnangagwa) would be the man who turned against me", he added.
With 5.6 million registered voters, the results of the presidential, parliamentary and local elections are due by August 4.
Other candidates include former Vice President and war veteran, Joyce Mujuru as well as senior politician, Elton Mangoma who represents a coalition of 9 political parties under Coalition of Democrats (CODE).
These include issues of investment, education, healthcare and jobs - some estimates suggest that the unemployment rate in Zimbabwe is as high as 90%.
Peter Nyoni is a Zimbabwean businessman who travels frequently between Harare and South Africa.
The most recent survey conducted by a research organization, Afro Barometer, put Mr Mnangagwa ahead of the rest of the candidates with 40%, followed by projected closest rival Mr Chamisa at 37%.
Mugabe defended Zimbabwe's election commission after Chamisa and the opposition raised concerns that the vote will be flawed, saying that "it acts quite freely".