Coach Mike Tomlin said in a statement that team doctors are evaluating the six-time Pro Bowler. Also, the three quarterbacks Brett Hundley, DeShone Kizer and Tim Boyle combined for 356 yards passing and three touchdowns.
"Ben Roethlisberger sustained a hit today in practice", Tomlin said through a team spokesman after practice.
Big Ben was already ruled out of Thursday's preseason game against Green Bay earlier in the day.
The 15th-year veteran has made four consecutive Pro Bowls despite missing some time.
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Roethlisberger has suffered three head-related injuries since entering the National Football League, according to sportsinjurypredictor.com, most recently suffering a concussion during the 2015 season.
He then managed to walk off the practice field under his own power alongside Pittsburgh general manager Kevin Colbert and head trainer John Norwig. The next thing I knew, the NFL was checking the football. "You like those challenges of seeing quality players".
"That's my guy", Gilbert said. "I've got to see the film to see what happened". He's coming to get his work in, throwing, [there's no] tackling.