As a result, the writer wracked up dozens of Emmy, Oscar, Tony and Golden Globe nominations and awards, as well as many other accolades, including the Pulitzer Prize and the Mark Twain Prize for American Humor.
Simon died early on Sunday (local time) of complications from pneumonia at New York Presbyterian Hospital in Manhattan, said Bill Evans, a longtime friend and spokesman for Shubert Organisation theatres.
Principally known for his original work on Broadway and subsequently in film, Simon cut his teeth as a writer for Sid Caesar's Your Show of Shows, along with other comedic greats like Mel Brooks, Carl Reiner and Selma Diamond.
At one point, in the late 1960s, he had four shows on Broadway at once. While his voice and comedy were decidedly East Coast and often reflected an ethnic Jewish experience, Simon's works played to packed houses around the world.
High level US-Russian talks in Geneva end without joint statement
His comments followed a joint statement by the United States, France and Britain on Tuesday that issued a similar warning. Syria has been gripped by civil war since March 2011. "Our objective is that all Iranian forces return to Iran".
In 1991 he won the Pulitzer Prize For Drama with Lost in Yonkers.
In total, Simon wrote more than 30 plays and earned 17 Tony nominations with three wins. He also wrote a couple of movies, including 1972's The Heartbreak Kid and 1977's The Goodbye Girl, the later of which was in turn adapted into a Broadway musical in 1993.
Neil Simon, the acclaimed American writer whose stage plays and films, like The Odd Couple and The Out-of-Towners, helped shape generations of American comedy, had died. "I thought it was a grim, dark play about two lonely men", he told the Paris Review in 1994, in an interview conducted by "Inside the Actors Studio's" James Lipton. In 1970, it was turned into a long-running television series with Jack Klugman and Tony Randall. He was also a Pulitzer Prize victor, among many other honors during a lengthy career. There's a Broadway theater named for him; he was the only living person to have received such recognition.
A statement from his representatives provided to Fox News confirms that his wife, Elaine Joyce Simon, and two daughters, Ellen and Nancy, were by his side when he died.