Williams sent down 13 aces and 30 winners to record her second consecutive straight sets victory at Flushing Meadows as the 36-year-old, who is hunting a record-equalling 24th Grand Slam title, wrapped up the win in one hour and seven minutes.
And the 23-time Grand Slam champion admitted that it is not easy to switch her mindset to beating Venus rather than hoping she wins. "[I am] introducing Serena, my first independent clothing line for all the ladies out there being awesome", Williams says about the brand.
However, she was reluctant to discuss Serena when asked to describe the specific challenges.
They've played each other in the finals of all four Slams, including at the US Open in 2001 (when Venus won) and 2002 (when Serena did).
She was ever-so-slightly more forthcoming during her on-court interview, joking, "The last time we played, at the Australian, it was two against one", a reference to the fact that Serena was pregnant when she beat Venus in the 2017 Australian Open final. We're both going to come out per usual and play our best in front of you guys. So cheer for me, cheer for Venus.
No. 16-seed Venus punched her ticket to the duel earlier in the day by fending off Camila Giorgi 6-4, 7-5 at Louis Armstrong Stadium.
Inbound Australian PM Scott Morrison gives his first address
But Dutton's campaign backfired when he lost the second contest to Turnbull's treasurer Scott Morrison by five votes. Treasurer of Australia Scott Morrison arrives for a party meeting in Canberra, Australia August 24, 2018.
Elina Svitolina advanced again after a stunning first-round exit at Wimbledon, as she looks to continue toward her first Grand Slam win and build off of a career-best fourth-round appearance in 2014.
"I was happy with a lot of things".
In other action, Sloane Stephens made it through after being taken to three sets by Anhelina Kalinina of Ukraine, the defending champion eventually winning 4-6, 7-5, 6-2. I think they both move extremely well. So I think that's the toughest part for me.
Elsewhere, two-time major champion Garbine Muguruza couldn't stave off an upset, leting a lead slip away in a stunning loss to 202nd-ranked Czech qualifier Karolina Muchova 3-6, 6-4, 6-4.