Despite the USA claiming three wins in the first six matches, halving one and losing only one, it wasn't almost enough to give themselves a chance as the Europeans won three of the next four matches to claim another Ryder Cup win on home soil (they haven't lost at home since 1993).
The Italian beat Phil Mickelson 4&2 to get Europe to the 14½-point winning mark, after America had threatened to stage an unlikely come back in winning three early points.
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At Medinah, Europe put the final two points on the board on Saturday, having been 10-4 down. Molinari made it official.
The celebration and singing had already begun.
Quite a contrast to the previous weekend, when he triumphantly strutted down the final fairway at East Lake, savoring his first victory in more than five years as thousands of fans stormed the course behind him. All that remained was Alex Noren in the anchor match.
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The United States' quest to win a Ryder Cup on European soil will have to wait at least four more years. Europe, though, are on the cusp of making a claim in the build up by one American scribe about the event being on the "verge of irrelevancy" due to the USA being set to embark on a "decade-plus of blowouts" look utterly absurd.
It was hardly what was expected from his first Ryder Cup appearance since 2012.
Europe captain Thomas Bjorn always believed in his friend, saying that going to Le Golf National without Garcia would be "like a football team going in without their captain". He wound up losing both his matches.
Woods finished 0-4, the worst record of any player in the competition, and the first time he's been shut out in eight Ryder Cups. He ended it by setting a more dubious Ryder Cup record with 22 losses. The point means Molinari is just the fourth man to go 5-0-0 in a Ryder Cup and the first to ever do it in the same year he won a major. "This team has been incredible". "We were determined to do the job".
The 2018 Ryder Cup built some drama for a short while during the Sunday singles matches, but in the end, Europe rolled to a clear victory after entering the day leading 10-6.
Reed will be in the 10th match out on the course on Sunday against Tyrrell Hatton, and USA captain Jim Furyk still has hopes that "Captain America" can still find his game at the ideal time. In the morning, they defeated Ian Poulter and (the winless) Jon Rahm 2&1.